Promising “quick relief,” Alka- Seltzer was first marketed on December 3, 1931 by Dr. Miles Medical Company of Elkhart, Indiana, according to the Smithsonian Institute. The new product combined aspirin with sodium bicarbonate, citric acid, and mono-calcium phosphate in an effervescent tablet. It was first conceived of as a cold tablet that would relieve headaches, upset stomach, and fever that accompanied the flu. The company’s advertising campaigns are hallmarks of popular American culture, the Smithsonian says.