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Pills for high blood pressure can prevent strokes, heart attacks


Two big studies offer good news to people with high blood pressure, finding that novel ways to use cheap drugs already on the market can lower their risk of heart attacks, stroke and death – even if they are very old.

Both studies were stopped early so the surprising benefits could be made known. Doctors presented results last week at an American College of Cardiology conference in Chicago.

“It is never too late to start” on blood pressure drugs, said Dr. Nigel Beckett of Imperial College in London, who led one study in the elderly that also was published online by the New England Journal of Medicine.

More than 70 million Americans have high blood pressure – readings of 140 over 90 or more – and only a third have it well controlled by medicines. Guidelines advise starting on one, usually a “water pill,” and adding others as needed.

With each new medication, “You get more pills, more copays,” said Dr. Kenneth Jamerson of the University of Michigan. “Our idea is, if you have to add on, why not do two right off the bat” in a single pill.

He led a study testing a single daily pill combining a diuretic and the ACE inhibitor benazepril versus a daily pill containing benazepril and a calcium channel blocker, amlodipine. ACE inhibitors dilate blood vessels to lower pressure. Calcium channel blockers do the same in a different way.

A total of 11,462 people in the United States and Nordic countries were given one combo or the other. Their average age was 68, and besides high blood pressure they were obese, had diabetes or other health problems.

Neither they nor their doctors knew which drugs they were taking until the study was stopped in October after it was clear that people on the ACE-calcium blocker combo were doing better.

Those people had about 20 percent fewer heart-related prob- lems or strokes – 526 among the 5,713 in this group versus 650 events among the 5,732 others, Jamerson said.

The study was paid for by Novartis, which sells Lotrel, the combo that proved better, and Jamerson consults for the company. The drugs are all sold as generics, although the doses in some require two pills a day instead of one.

The findings could shape treatment guidelines due to be reviewed in a few months, said Dr. Daniel Jones, a University of Mississippi blood pressure specialist and president of the American Heart Association.

Doctors can start with a combination, but few do, partly for lack of evidence, he said.

Guidelines also may change to reflect a second study that found dramatic benefits for treating people in their 80s, an age when blood pressure drugs were not known to be safe or effective.

“The over-80s are the most rapidly expanding segment of our population,” and the prevalence of blood pressure rises as people age, Beckett noted.

His study assigned 3,845 older people in Europe, China and several other countries to take the diuretic indapamide or dummy pills plus the ACE inhibitor perindopril as needed to reach a goal of 150/80 from an average starting pressure of 173/ 91.

The study was stopped last July after monitors saw that those on the diuretic had 39 percent fewer fatal strokes and 21 percent fewer deaths from any cause – benefits far exceeding what researchers predicted.

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